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KMID : 0858420040060020125
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Korean Journal of Stroke
2004 Volume.6 No. 2 p.125 ~ p.132
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Platelet Glycoprotein IIb/IIIa Receptor Antagonists for theTreat-ment of Acute Ischemic Stroke:a Neurointerventionist’s Review
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이덕희/Lee DH
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Abstract
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Introduction
The basic concept of recanalization treatmentof acute ischemic stroke is early removal ofthrombi occluding the cerebral vessels beforethe ischemic brain tissue injured irreversibly.The mission can be achieved by mechanicaland/or pharmacologic methods. Figurativelyspeaking, it is a battle with thrombi. To win thebattle we need to know about the thrombuswhich is composed largely of platelet aggregatesand fibrin networks. Traditionally fibrinolyticshave been applied as the primary pharmaceuti-cals, which are not always successful regardlessof the delivery methods. Theoretically approach-ing both aspects, fibrinolysis and antiplateletaction, will be more efficient because they maypotentiate the clot lysis. This paper will brieflyreview a relatively recent antiplatelet drug,platelet glycoprotein (GP) IIb/IIIa receptor antag-onist which can be used in that purpose togeth-er with fibrinolytics. For the convenience, theaction of platelets in the formation of thrombuswill be reviewed shortly first.
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KEYWORD
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